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KMID : 0614720200630010030
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Journal of Korean Medical Association
2020 Volume.63 No. 1 p.30 ~ p.35
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Drug-induced nephrotoxicity
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Bae Eun-Jin
Lee Tae-Won
Park Dong-Jun
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Abstract
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Drugs are a common cause of acute and chronic kidney disease and contribute to patient morbidity and increased healthcare utilization. Drug-induced nephrotoxicity is approximately 14% to 26% in adults and tends to increase among certain patients and/or with complex clinical conditions. Unfortunately, apart from conservative management, including drug withdrawal, no effective treatment is known for this condition. Therefore, in order to reduce the frequency of drug-induced nephrotoxicity, early recognition of renal toxicity and appropriate prevention strategies, such as understanding the exact mechanisms of renal injury, patient and drug-related risk factors, and preemptive measures are needed. In this review, we will present the mechanisms of drug-induced nephrotoxicity and general preventive strategies for clinical physicians.
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KEYWORD
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Glomerulus, Kidney tubules, Renal insufficiency, Pharmaceutical preparations, Toxicity
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